The active ingredient is represented by the chemical structure. In a multipledose pharmacokinetic study in male volunteers following 2 days of 5 or 10 mg of oral pilocarpine hydrochloride tablets given at 8 a. May cause eye, skin, or respiratory system irritation. Dec 08, 2016 isopto carpine pilocarpine hydrochloride ophthalmic solution 1%, 2% and 4%. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. Important update all sales after march 2, 2020 are final and nonreturnable for covid19 related items. Pilocarpine hydrochloride northwest missouri state.
Inquire about dmf, cgmp, price, availability, samples, sourcing, purity and more. Pilocarpine belongs to a class of drugs known as cholinergic agonists. Buy pilocarpine hcl generic isopto carpine, pilocar, salagen. It has also been used to induce status epilepticusse in rat. Concentration pilocarpine hydrochloride 54717 2002125 614017001 sheets you need to deploy. Nov 09, 2018 pilocarpine affects the nervous system and increases saliva secretion in the mouth. Colorless, translucent crystals or white crystalline powder function. Pdf pilocarpine toxicity and the treatment of xerostomia. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. The following table lists the ndcs and labelers of pilocarpine hydrochloride. Safety data sheet according to federal register vol. We will continue to use fair share allocation of otc product to combat shortages and strive to get orders out in a timely manner. How to use pilocarpine hcl drops to apply eye drops, wash your hands first. Nov 30, 2017 systemic exposure to pilocarpine was evaluated in 14 healthy subjects administered 2 drops of pilocarpine hydrochloride ophthalmic solution 4% to both eyes four times daily for eight days.
Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Pilocarpine ophthalmic for the eyes is used to treat glaucoma or ocular hypertension high pressure. Buy pilocarpine hcl generic isopto carpine, pilocar. Take this medication by mouth with or without food, usually 34 times daily, or as directed by your doctor to reduce your risk of side effects, your doctor may direct. Pilocarpine hydrochloride is a hygroscopic, odorless, bitter tasting white crystal or powder which is soluble in water and alcohol and virtually insoluble in most nonpolar solvents. Synonyms pilocarpine hcl unii 0ww6d218xj cas number 54717 weight average. Safety data sheet memorial university of newfoundland. Some combination preparations of pilocarpine contain sodium bisulfite and should be used with caution in patients with a known sulfite hypersensitivity, especially in patients with a history of asthma. Pilocarpine is used to treat dry mouth caused by sjogrens syndrome, or by radiation to treat head and neck cancer. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. Pilocarpine eye drops fda prescribing information, side. Pilocarpine hcl is a nonselective muscarinic acetylcholine receptor agonist. The amount of isopilocarpine found ranged from 1 to 6. This medicine may help you speak without having to sip liquids.
Pilocarpine side effects, dosage, interactions drugs. Salagen pilocarpine hydrochloride dose, indications. Pilocarpine ophthalmic for the eyes is used to treat glaucoma or. Pilocarpine hydrochloride tablets contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Pilocarpine tablets are used to treat dryness of the mouth and throat caused by a decrease in the amount of saliva that may occur after radiation treatment for cancer of the head and neck or in patients with sjogrens syndrome. Pilocarpine ophthalmic drops, solution 1pct drug medication. Pilocarpine affects the nervous system and increases saliva secretion in the mouth.
Pilocarpine is used to treat dry mouth caused by sjogrens syndrome, or. Packaging 5, 10, 50 g in poly bottle biochemphysiol actions pilocarpine is alkaloid isolated from the shrub pilocarpus species. A comparison of c max values on days 5 and 8 indicated that pilocarpine concentrations in plasma reached steadystate following topical administration of. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. Isopto carpine pilocarpine hydrochloride ophthalmic solution is a cholinergic agonist prepared as a sterile topical ophthalmic solution. Stability of pilocarpine hydrochloride and pilocarpine. Pilocarpine reduces the amount of fluid in the eye, which decreases pressure inside the eye.
Pilocarpine may stimulate the mucous cells of the respiratory tract and increase bronchial smooth muscle tone and airway resistance. Pilocarpine ophthalmic side effects, dosage, interactions. When pilocarpine is used to treat dry mouth caused by radiotherapy in people who have head and neck cancer, it is usually taken three times a day. It works by stimulating certain nerves to increase the amount of saliva you produce, making it easier and more comfortable to speak and swallow. Pilocarpine hydrochloride 54717 451538902 cymit quimica s. Material may be irritating to the mucous membranes and upper respiratory tract. Salivary gland scintigraphy was positive for damage to glands. As eye drops it is used to manage angle closure glaucoma until surgery can be performed, ocular hypertension, primary open angle glaucoma, and to bring about constriction of the pupil following its dilation. Identification of the substancemixture and of the company undertaking. Pilocarpine oral tablet 5mg drug medication dosage information. Jan 01, 2017 pilocarpine tablets are used to treat dryness of the mouth and throat caused by a decrease in the amount of saliva that may occur after radiation treatment for cancer of the head and neck or in patients with sjogrens syndrome.
Pilocarpine hydrochloride monograph for professionals. Pilocarpine works by causing the pupil of the eye to shrink and decreasing the amount of fluid within the eye. Pilocarpine hydrochloride ophthalmic solution is a cholinergic agonist prepared as a sterile topical ophthalmic solution. When pilocarpine is used to treat dry mouth in people who have sjogrens syndrome, it is usually taken four times a day. Pilocarpine hydrochloride can be used in the medical management of glaucoma, especially openangle glaucoma, in those cases in which the intraocular pressure can be controlled adequately by the topical administration of pilocarpine. Pilocarpine hydrochloride pilocarpini hydrochloridum contd. Following oral administration of pilocarpine the elimination halflife ranges from 0. Pilocarpine and its degradation products are excreted in the urine. Certificate of analysis coa product information sheet pdf. Each ml of pilocarpine hydrochloride ophthalmic solution contains. Chemical product and company identification product name.
Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Although pilocarpine salts in ophthalmic solution decompose into isopilocarpine. Pilopine hs pilocarpine hydrochloride ophthalmic gel 4%. Eight samples of pilocarpine hydrochloride had tablets that exceeded the usp upper limit for strength. Pilocarpine hydrochloride information, side effects, warnings. Pilocarpine hydrochloride can be used in the medical management of glaucoma, especially. One reagent lane fair lawn, nj 07410 for information in north america, call. Pilocarpine hydrochloride dosage and administration administration oral administration. Pilocarpine hydrochloride ophthalmic solution is a muscarinic cholinergic agonist indicated for the reduction of elevated intraocular pressure iop in patients with openangle glaucoma or ocular hypertension the management of acute angleclosure glaucoma the prevention of postoperative elevated iop associated with laser surgery the induction of miosis.
Salagen pilocarpine hydrochloride tablet, film coated. Pilocarpine hydrochloride ophthalmic solution 1%, 2%, and 4% has been used as a miotic for the clinical therapy of primary openangle. Pilocarpine is a medication used to reduce pressure inside the eye and treat dry mouth. Salagen tablets contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Pilocarpine hydrochloride has been used to stimulate salivary secretions in mice. Section 1 chemical product and company identification.
Systemic exposure to pilocarpine was evaluated in 14 healthy subjects administered 2 drops of isopto carpine pilocarpine hydrochloride ophthalmic solution 4% to both. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Safety data sheet northwest missouri state university. Lgm pharma offers this active ingredient but not the finished dosage forms. Nov 09, 2018 pilocarpine reduces the amount of fluid in the eye, which decreases pressure inside the eye. It may also help with chewing, tasting, and swallowing. Pilocarpine is a natural alkaloid extracted from plants of the genus pilocarpus with cholinergic agonist activity. Pilocarpine hydrochloride information, side effects. Choose how to save on pilocarpine hcl in redmond, wa 98052 home delivery how it works fast.
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